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Thread: Zoloft

  1. #1


    So I've been taking Zoloft for the past 3 weeks or so to help with my depression and mood swings. I really like the way it helps me handle things. Instead of freaking out and acting like it is the end of the world if something small goes wrong, I am calm and shrug it off, "hey, its no big deal". I like how I am on this medicine, and my boyfriend does too. I would recommend Zoloft to anyone who is feeling like they need something to help stabilize their moods.
    &quot;How grateful I was then to be part of the mystery, to love and to be loved. Lets just hope that is enough.&quot;<br />-Conor Oberst

  2. #2

    Re: Zoloft

    Zoloft (sertraline) is an effective SSRI anti depressant well tolerated by many people. One consideration for anyone taking Zoloft, is that SSRIs (including Zoloft sertraline) are potent inhibitors of the hepatic isoenzyme P450-2D6 and would be expected to have effects on the clearance of drugs metabolized by this enzyme.

    The practical aspect of this interaction is that many prescription and even over the counter medications are metabolized by this enzyme, so it would be recommended to consult one of the many drug interaction checkers online to ensure you are not experiencing drug interactions.

    Be sure to mention to all your physicians and pharmacists the list of medications you take, to avoid drug interactions, which can reduce the effectiveness of some meds or cause unexpected side effects when interacting medications are taken together.

    Dum spiro spero....While I breathe, I hope

    Tourette Canada Forum

  3. #3

    Re: Zoloft

    I'm very happy to hear that it's working for you, Mia. It must be a real relief to you to feel more in control of your feelings and emotional reactions.

  4. #4

    Re: Zoloft

    I'm glad to hear you've found something that works for you. I've been on Zoloft for about two years now and I too, think its a good medication.
    I hope it continues to work so well for you.

  5. #5

    Re: Zoloft

    Thanks everyone for the replies. I finally am starting to feel like I have control over my life and my emotions.
    &quot;How grateful I was then to be part of the mystery, to love and to be loved. Lets just hope that is enough.&quot;<br />-Conor Oberst

  6. #6

    Re: Zoloft

    That is really great news that Zoloft is working so well for you Mia!

    I actually have a Zoloft question mother had been on Zoloft for about 10 years (a pretty heavy dose). She was always in a super good mood. Due to changes in insurance coverage she had to switch to a different anti depressant or pay a lot more for Zoloft. Her primary care doctor chose Prozac to put her on. Is that comparable to Zoloft? The reason I ask is that now my mom seems really depressed. Granted, she has every reason to be, her mother died, family estrangements, etc...but I can't help but wonder if the change in anti depressents is exacerbating the down mood.

    Is Prozac a good alternative to Zoloft?

  7. #7

    Re: Zoloft

    Is Prozac a good alternative to Zoloft?
    As you know both medications are in the same class of meds, Selective Seretonin Reuptake Inhibitors (SSRI)

    How long has the switch to been? The half life of Prozac (fluoxetine) is longer than that of Zoloft (sertraline) and requires a couple of weeks to achieve a steady state blood level...the point where the amount eliminated equals the amount ingested.

    The interesting thing about SSRI's is that they do not necessarily have the same effectiveness in all people, and it is not uncommon for the doctor to change from one to another until the right compound is found for a particular person.

    The options your mother might consider would be to ask for a referral to a specialist who can fine tune the dosage or change to another compound which will relieve her symptoms. Though most Family Physician's have a good working knowledge of SSRI's, if a patient has difficulty tolerating the medication or needs changes to control symptoms, a specialist such as a Psychiatrist usually has a better degree of expertise in managing this type of medication.

    Depending on your mother's financial means, she may be eligible to apply to the manufacturer of the medication she tolerates best for a compassionate supply. This would have to be pursued through her physician.

    In any case, your mother should see her physician and report the change in mood in addition to the added current stressors in her life. Continued communication with the prescribing physician is the best way to manage one's treatment, because situations change, resulting in changes to the treatment plan.


    Dum spiro spero....While I breathe, I hope

    Tourette Canada Forum

  8. #8

    Re: Zoloft

    To add to TSOW's comments, I would say that there's no reason normally to expect that Prozac would not be a good alternative to Zoloft - it might even have some benefits, But as you not, she is dealing with some additional stressors and triggers at the moment and no reasonable amount of medication will shield her from all of the fallout of those factors.

  9. #9

    Re: Zoloft

    Thank you both for answering. I'm relieved to know that at least her general doctor was heading in the right direction. I agree that she should see a psychiatrist, and I suggested such, but she seems unwilling to go (although she was always all for me going). I think now, that she is simply too depressed to "put in all the energy to find someone" as she put it. It's been about a month since the death and 3 weeks since the medication change.

    It is hard to watch a formerly happy person become such a shell of who they usually are. I had also encouraged her about the good effects (I had heard about) of the Prozac, but at this point I think I can safely say she is not experiencing any good effects from it. She used to be almost overly happy with Zoloft-nothing could bother her, ever. The change in her is just really extreme.

    Thanks again for your answers. They were very helpful.

  10. #10

    Re: Zoloft

    She made need to adjust the dose of Prozac, too - do you know how much she's taking now? Perhaps she would be willing to discuss that with her doctor. After three weeks, she should be seeing benefits, since this isn't her first SSRI.

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