NIMH Science Update
April 1, 2006

Studies Offer New Information About Treatment Choices for Schizophrenia

A national clinical trial comparing clozapine with other new-generation antipsychotic medications for the treatment of chronic schizophrenia has shown that people who switched to clozapine from their first medication because it failed to manage symptoms adequately, were twice as likely to continue treatment as patients who switched to other antipsychotic medications. A companion study found that for people who switched to new-generation antipsychotic medications other than clozapine, those who took olanzapine and risperidone continued taking their medication longer than people taking quetiapine and ziprasadone. The results of the trial, which was funded by the National Institute of Mental Health (NIMH), part of the National Institutes of Health, were published in two papers in the April 2006 issue of the American Journal of Psychiatry.

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