
Originally Posted by
Dr. Fawver
We're getting a lot of benefit from using the atypical antipsychotic medications for augmentation for unipolar depression. Zyprexa, for instance, increases the norepinephrine and dopamine in the prefrontal cortex. By doing that, you can add on Zyprexa with an SSRI at 10 mgs at bedtime and sometimes get an augmentation to your antidepressant effect. Risperdal, at doses as small as 1 mg at bedtime, can augment an antidepressant because Risperdal is indirectly affecting the serotonin transmission by blocking serotonin two-way receptors. So, yes, the atypical antidepressant medications can certainly be used for augmentation with the antidepressants. Even if a person does not have psychotic depression and even if a person does not have bipolar depression.
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