More threads by David Baxter PhD

David Baxter PhD

Late Founder
Antipsychotics Suppress Symptoms of Obsessive-Compulsive Disorder

NEW YORK (Reuters Health) Jul 13, 2005 -- The antipsychotic agents risperidone and haloperidol reduce manifestations of obsessive-compulsive disorder (OCD) when used as add-on therapy with an antidepressant, results of a small crossover trial suggest.

Serotonin reuptake inhibitor (SRI) antidepressants are commonly used to treat OCD, but approximately half of patients do not respond to SRI monotherapy.

Dr. Xiaohua Li, from the University of Alabama at Birmingham, and associates performed a double-blind trial involving 12 patients with severe OCD who were on stable SRI doses. The subjects took risperidone 1 mg/day, haloperidol 2 mg/day or placebo for 2 weeks each in a crossover fashion, with a 2-week placebo washout between treatments. They underwent weekly assessments.

As reported in the June Journal of Clinical Psychiatry, both drugs reduced scores on the Yale-Brown Obsessive Compulsive Scale compared with placebo (placebo 9.23; risperidone, 7.07, p = 0.014; haloperidol 6.70, p = 0.006).

"Considering that the patients had severe residual symptoms during SRI treatment, a significant reduction in obsession within 2 weeks of treatment initiation with each drug is notable," the authors comment.

The team also observed a tendency to lower compulsion scores, and both drugs significantly reduced anxiety scale scores (p = 0.004 and 0.014, respectively).

Risperidone but not haloperidol was associated with lower scores on the Hamilton Rating Scale for Depression and an enhanced sense of well-being according to Profile of Mood States.

Five subjects discontinued haloperidol before the 2-week phase was complete due to dystonia or severe lethargy. All the participants completed the risperidone phase. Results of neuropsychological tests indicated that neither drug changed cognitive function.

The investigators suggest that longer duration of treatment may result in an even better reduction in symptoms.

J Clin Psychiatry 2005;66:736-743.
Abilify i have found allows better thinking more clarity as doctor said to someone i know you are thinking now before there was not logical thought pattern now that person is able to reason more
Two years ago I took my prescribed trazodone and took a walk about 10PM (after a tiff with my mom) and I got so tired that I slept behind a Braum's trashcan. (I don't drink but the workers at Braums must have thought I was drinking which I wasn't LOL) but when I woke up I saw witches everywhere and heard them talking to me. Mom said that there were no witches I was hallucinating. I mentioned this to my pdoc and he put me on risperdal 2 mg. and also fanapt 20 mg. which is also used for preventing psychosis. I haven't had one hallucination since.
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