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Retired

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Sleep aids: Could antihistamines help me sleep?
By Mayo Clinic staff

Is it OK to use over-the-counter antihistamines to treat insomnia? I'd like to avoid prescription sleep aids.

Answer
from Timothy Morgenthaler, M.D.

Antihistamines can cause drowsiness, which may help you fall asleep for a few nights ? but routine use of antihistamines for insomnia isn't recommended.

Antihistamines induce drowsiness by working against histamine, a chemical produced by the central nervous system. In fact, most over-the-counter sleep aids contain antihistamines. These products are intended to be used for only two to three nights at a time, however, such as when stress, travel or other disruptions keep you awake. Tolerance to the sedative effects of antihistamines can develop quickly ? so the longer you take them, the less likely they are to make you sleepy. Side effects may include daytime drowsiness, dry mouth, dizziness and memory problems.

If you're struggling with chronic insomnia, don't rely on antihistamines or other over-the-counter sleep aids for a good night's sleep. Lifestyle changes ? rather than sleep aids ? are usually the best approach. Start with the basics, such as:

  • Following a regular sleep schedule
  • Avoiding caffeine and daytime naps
  • Including physical activity in your daily routine
  • Managing stress

If you continue to have trouble falling or staying asleep, consult your doctor. In addition to lifestyle changes, your doctor may recommend behavior therapy to help you learn new sleep habits and ways to make your sleeping environment more conducive to sleep. In some cases, short-term use of prescription sleep aids may be recommended as well.
 

Retired

Member
Additionally, even though antihistamine sleep aids are sold over the counter they are not entirely free from all risk. There are a number of medical conditions with which this type of medication should not be used.

There is also potential for drug interactions with both prescription and nonprescription medications, especially with: sleeping pills, sedatives, tranquilizers, muscle relaxants, medication for depression, seizure medications, narcotic pain relievers, other medications for colds/hay fever/allergies.
 
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