How do I know if my medication is really working or it's a placebo,effect. I am confused because I have been reding in the media that antidepressants work no better than placebos, but my setraline seems to be helping my OCD. If this is a placebo effect than I would rather know now than continue to take this drug. I was taking seroquel too but I have cut down on it as its too sedating for me.