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David Baxter PhD

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Two Virus Stories
The New York Times
Nov 10, 2020

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A temporary hospital for coronavirus patients in MoscowCredit...Natalia Kolesnikova/Agence France-Presse — Getty Images

There are two very different coronavirus stories happening now.

The first story is grim: Worldwide, the virus is spreading more rapidly than at any other point. The U.S. and Europe are both setting records for new confirmed cases, while South America, North Africa, India and other regions are coping with serious outbreaks.

The spread is bad enough that harsh measures — like again shutting some restaurants or banning indoor gatherings — may be necessary to get it under control. Much of Europe has taken such steps in recent weeks. President Trump has opposed them. But President-elect Joe Biden, in appointing a 13-member virus task force yesterday, emphasized that he would take a radically different approach and base his policy on scientists’ advice.

“These are some of the smartest people in infectious diseases,” my colleague Apoorva Mandavilli, a science reporter, said about the task force’s members. Biden, who has worn a mask in public for months, may also be able to increase mask-wearing by delivering a more consistent message about it than Trump has, Apoorva added. Yesterday, Biden implored Americans to wear masks, saying: “Do it for yourself. Do it for your neighbor.”

No matter what, though, much of the world will probably be coping with severe outbreaks — and thousands more deaths each day — for months to come.

The second story is much more encouraging. It’s the rapid progress that medical researchers are making on both potential vaccines and treatments that can ameliorate the virus’s worst symptoms.

Pfizer announced yesterday that early data showed its vaccine prevented Covid-19 in more than 90 percent of trial volunteers. Other companies, including Moderna and Novavax have also reported encouraging news about their vaccines. (The Times’s Carl Zimmer and Katie Thomas answer some common vaccine questions here.)

Even before any vaccine becomes widely available, virus treatment is already improving, thanks to earlier diagnoses and drugs like dexamethasone and remdesivir. The Food and Drug Administration granted emergency authorization yesterday to an Eli Lilly treatment that doctors recently gave to Chris Christie, the former New Jersey governor.
The improving quality of treatments is evident in the death rate: Only about 1.5 percent of diagnosed cases have been fatal in recent weeks, compared with 1.7 percent in late July and early August, and 7 percent during the virus’s initial surge in the early spring.

As these charts show, U.S. deaths have stayed in a narrow range — albeit at a terribly high level — even though cases have been surging since September:

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The New York Times | Sources: State and local health agencies and hospitals

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The New York Times | Sources: State and local health agencies and hospitals

The full picture, via Ashish Jha, dean of Brown University’s public health school: “We all need to keep two seemingly contradictory facts in mind: 1. We are entering the hardest days of the pandemic. The next two months will see a lot of infections and deaths; 2. There is a light at the end of the tunnel. Today, that light got a bit brighter.”
 

Daniel E.

daniel@psychlinks.ca
Administrator

Daniel E.

daniel@psychlinks.ca
Administrator
Will Thanksgiving Be a COVID-19 Disaster? It Was in Canada | Time
November 12, 2020

...Nearly 2 in 5 Americans are planning on gathering with more than 10 people this Thanksgiving, according to a new Ohio State University survey. So what can people do to try to reduce the danger if they insist on getting together in person?

“All this virus needs is close contact for a prolonged period of time, and especially indoors, because there’s poorer ventilation,” says Oughton. Distancing is better than not distancing, he says, and having an outdoor celebration, where the weather allows, is also preferable, given the better natural ventilation. If you can’t have Thanksgiving outdoors, Oughton says, consider keeping the windows open to improve ventilation, or rethinking how you seat people. “Can you have people seated farther away, so instead of just the one family table, can you have a few smaller tables?” he says. “Or do you have people get their food and sit down, but again with distancing so at least you can be together and have a meal together even if you’re still sitting at least six feet apart?”

Still, Oughton echoes the advice of many other public-health experts, saying that it’s better to connect with extended family online this year to help ensure everyone’s happy and healthy for next year’s holiday season—especially given that some family members, like grandparents, are more vulnerable to severe COVID-19 due to age and other potential factors...
 
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Daniel E.

daniel@psychlinks.ca
Administrator
ICU nurse who treats COVID-19 patients - CBS News
November 14, 2020

"It's hard to watch someone struggling to breathe and see the regret that they have - the regret for just not wearing a mask, or maybe not going to a party, or maybe not going to that wedding or not going to that church service," Mobley said. "In the end, people are dying because they just didn't realize the seriousness of that situation. And It's hard to watch."
 

Daniel E.

daniel@psychlinks.ca
Administrator
Moderna's coronavirus vaccine is 94.5% effective, according to company data - CNN
Nov. 16, 2020

The Moderna vaccine is 94.5% effective against coronavirus, according to early data released Monday by the company, making it the second vaccine in the United States to have a stunningly high success rate.

"These are obviously very exciting results," said Dr. Anthony Fauci, the nation's top infectious disease doctor. "It's just as good as it gets -- 94.5% is truly outstanding."

...Fauci says he expects the first Covid-19 vaccinations to begin "towards the latter part of December, rather than the early part of December."

Initially, there won't be enough vaccine for everyone. The highest priority groups, which include health care workers, the elderly, and people with underlying medical conditions, will get the vaccine first.

"I think that everybody else will start to get vaccinated towards the end of April," Fauci said. "And that will go into May, June, July. It will take a couple of months to do."

...While the two vaccines appear to have very similar safety and efficacy profiles, Moderna's vaccine has a significant practical advantage over Pfizer's.

Pfizer's vaccine has to be kept at minus 75 degrees Celsius. No other vaccine in the US needs to be kept that cold, and doctors' offices and pharmacies do not have freezers that go that low.

Moderna's vaccine can be kept at minus 20 degrees Celsius. Other vaccines, such as the one against chickenpox, need to be kept at that temperature.

That means Moderna's vaccine can be kept in "a readily available freezer that is available in most doctors' offices and pharmacies," Zacks said. "We leverage infrastructure that already exists for other marketed vaccines."

Another advantage of Moderna's vaccine is that it can be kept for 30 days in the refrigerator, the company announced Monday. Pfizer's vaccine can last only five days in the refrigerator.
 
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