David Baxter PhD
Late Founder
Going back to the very beginning of this discusssion, I pointed out that clonazepam utilizes cytochrome P-450 for its metabolism as well. This competition for the enzyme may result in higher than expected blood levels of trazodone, causing unexpected adverse effects.
50 mg of trazodone is a very low dose, so even if the result is higher blood levels it's still unlikely to be a concern.
Your doctor is probably aware of this intereaction potential and has likely modified the dosage accordingly, but this is a subject worthy of discussion with the doctor as well as the pharmacist.
Almost certainly, since trazodone and clonazepam are not new medications and the potential for interaction is well known.