I have spent the last month withdrawing from Effexor (225 mg daily) by using prozac (20 mg daily) under the supervision of a pchyciatrist. I was on Effexor for 8 years. It was getting to the point that I was suicidal, paranoid and extremely anxious while on the Effexor over the last couple of years. I feel better now. How long this will last - who knows? One thing I do know - I would never take any form of venlafaxine, including Pristiq, because of the difficulty of getting off of it. While it isn't addictive in the same way cocaine is, the withdrawal symptoms are just as brutal.