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NIH Dietary Supplement Fact Sheet: Vitamin D

Vitamin D Interactions with Medications
Vitamin D supplements have the potential to interact with several types of medications. A few examples are provided below. Individuals taking these medications on a regular basis should discuss vitamin D intakes with their healthcare providers.

Steroids
Corticosteroid medications such as prednisone, often prescribed to reduce inflammation, can reduce calcium absorption [90,91,92] and impair vitamin D metabolism. These effects can further contribute to the loss of bone and the development of osteoporosis associated with their long-term use [91,92].

Other medications
Both the weight-loss drug orlistat (brand names Xenical? and alli?) and the cholesterol-lowering drug cholestyramine (brand names Questran?, LoCholest?, and Prevalite?) can reduce the absorption of vitamin D and other fat-soluble vitamins [93,94]. Both phenobarbital and phenytoin (brand name Dilantin?), used to prevent and control epileptic seizures, increase the hepatic metabolism of vitamin D to inactive compounds and reduce calcium absorption [95].

Complete information regarding Vitamin D HERE
 
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