More threads by David Baxter PhD

David Baxter PhD

Late Founder
Yo-Yo Weight Loss May Impair Immunity
Mon Jul 12, 2004
by Megan Rauscher

NEW YORK (Reuters Health) - Frequent intentional weight loss may have significant long-term detrimental effects on the immune system, study results show, while maintaining a healthy weight benefits immune function.

"There are clear health benefits to reducing body weight among those who are overweight or obese," Dr. Cornelia M. Ulrich commented to Reuters Health. "Our main concern is the pattern of weight cycling or yo-yo dieting that many go through."

Ulrich, from the Fred Hutchinson Cancer Research Center in Seattle Washington, and her colleagues studied 114 healthy, overweight sedentary postmenopausal women. The team found that the immune function of so-called natural killer (NK) cells was significantly lower in those who had ever intentionally lost 10 pounds or more compared with those without this history.

Moreover, the cell-killing ability (or "cytotoxicity") of NK cells was "increasingly lower" with the number of times a woman reported shedding 10 pounds or more, the investigators report in the Journal of the American Dietetic Association.

"Two or more episodes were associated with substantially decreased NK cytotoxicity, with the lowest NK cytotoxicity seen in those reporting the highest frequency of weight loss," they say. According to the team, frequent intentional weight loss reduced both the proportion and absolute number of NK cells.

Maintaining a stable weight over several years, on the other hand, was associated with significantly greater NK cell numbers and cytotoxicity.

The public health implications are "potentially substantial in that intentional weight loss is common and may become even more common if the prevalence of obesity continues to increase," Ulrich and her colleagues write.

"Lower NK cytotoxicity could contribute to an increased incidence of viral infections, and thus, to lost productivity or decreased quality of life," they warn.

Ullrich concluded, "We suggest a sensible approach to weight loss that combines dietary changes with regular exercise. Exercise may be key, in that it helps to keep weight off and also may boost the immune system."

SOURCE: Journal of the American Dietetic Association, June 2004.
 

Similar threads

Food diary may boost weight loss Tuesday, July 8, 2008 NEW YORK (Reuters Health) - People who keep a journal to track their eating habits may be more successful at shedding pounds, according to research published Tuesday. In a study of nearly 1,700 overweight adults in a weight-loss program, researchers found that those who wrote in a "food diary" every day lost twice as much weight over six months as those who did not keep a journal. The findings, published in the American Journal of...
Replies
0
Views
1K
Weight Loss Surgery and Eating Disorders Dr. Kristine Vazzano, Mirror-Mirror.org Written 2016. Retrieved October 19, 2017 As rates of obesity in the United States rise, weight loss surgery (commonly known as bariatric surgery), is gaining popularity as a weight loss alternative. Many medical professionals recommend bariatric surgery to assist patients in managing their weight and improve health problems attributed to obesity. Although many people who undergo bariatric surgery lose...
Replies
1
Views
7K
Weight-loss apps 'missing' key strategies CBC News October 7, 2013 Weight-loss mobile apps lack most of the behavioural strategies people need to stay motivated and on track, a new study suggests. In Tuesday's online issue of the American Journal of Preventive Medicine, researchers looked at 30 weight-loss apps for iPhone and Android platforms to see if they included any of the 20 behavioural strategies that previous studies showed were effective for weight-loss and reducing risk for...
Replies
0
Views
1K
Weight-loss supplements deemed a waste of money CBC News Mar 7, 2012 Of hundreds of products in U.S. study, only a handful can produce modest weight loss Weight-loss supplements advertised as fat blockers, appetite suppressants or body-composition changers usually have little effect — especially over the long term — and may even harm you, according to a new U.S. study. Of the hundreds of products reviewed by Oregon State University researcher Melinda Manore, many were scrutinized in...
Replies
0
Views
1K
Top