More threads by David Baxter PhD

David Baxter PhD

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Fever can unlock autism's grip temporarily
Mon., Dec. 3, 2007

Elevated temperature can restore cell communication in brain, study finds

CHICAGO - Fever can temporarily unlock autism's grip on children, a finding that could shed light on the roots of the condition and perhaps provide clues for treatment, researchers reported on Monday.

It appears that fever restores nerve cell communications in regions of the autistic brain, restoring a child's ability to interact and socialize during the fever, the study said.

"The results of this study are important because they show us that the autistic brain is plastic, or capable of altering current connections and forming new ones in response to different experiences or conditions," said Dr. Andrew Zimmerman, a pediatric neurologist at Baltimore's Kennedy Krieger Institute, who was one of the study authors.

The study, published in the journal Pediatrics, was based on 30 children with autism aged 2 to 18 who were observed during and after a fever of at least 100.4 degrees Fahrenheit.

More than 80 percent of those with fever showed some improvements in behavior during it and 30 percent had dramatic improvements, the researchers said. The change involved things like longer concentration spans, more talking, improved eye contact and better overall relations with adults and other children.

Zimmerman's team said the fever effect had been noted anecdotally in the past by parents and doctors.

Lee Grossman, president and chief executive officer of the Autism Society of America, said he had noticed it in his own son, who is now 20.

But he noted in an interview that the study's authors said expanded research was needed on the fever effect and its implications. "It's good that they've noticed this and are bringing it forward," he said.

Reconnecting autistic brain
People with autism spectrum disorders suffer in varying degrees from limited social interactions, lack of verbal and non-verbal communication and other abilities.

As many as 1.5 million Americans have some form of autism, according to ASA. It is not known what causes the condition.

Zimmerman said that while there currently is no definitive medical treatment, speech and language therapy started as soon as possible after diagnosis "can make a significant difference."

He called the fever research, headed by colleague Laura Curran, "an exciting lead" that could help point the way to a treatment that would reconnect the autistic brain. He said the fever effect was believed found only in children, whose brains are more "plastic" than those of adults.


That is really interesting. I'm not sure if this is related or not, but I've noticed (to the point of mentioning it to parents) that when some kids are sick, particularly the kids that are naturally hyperactive and have trouble sitting still, that when they get colds or otherwise seems sick (it is always a little hard to tell exactly what the illness is because often they can't explain how they feel) that they seem to be capable of doing better work, sitting for longer, concentrating more, better behavior. Anyway, I always attributed it to less energy but I wonder now if it's more than that.


One of the children I recently began to work with, a 7 year old boy, is severely autistic and tests in the profoundly mentally retarded range. He is completely non-verbal, lacks any functional means of communication(e.g., PECS, sign language) and is not toilet trained. He engages in many interfering responses including head-banging, pica and vocal & motor stereotypies that occur on average 90% of his waking day. He has difficulties distinguishing between environmental cues (e.g., show me your head, vs show me your feet) even when mastered in isolation, fails to make eye contact, and at times bites and pulls hair. It's very difficult to get him to sit and attend for even 1 minute. BUT - when he has a fever we get the all time best results. When he is physically exhausted from the fever and related illness the effort to engage in the aberrant responses is too great, and therefore decreases (my own hypothesis). It's very sad - because we see what he is capable of, but he often fails to engage in appropriate behavior when he is not ill. But it makes me all the more determined to find a way to make engaging in socially appropriate responses as reinforcing as the aberrant ones! Obviously, this is just anecdotal - but still interesting that I had observed this trend in him and read this post here! Thanks!
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