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“MEDICATION TREATMENT of Tourette Syndrome”
PRESENTATION BY DR DANIEL GORMAN


article by L Zuker and J Temple

Please note that the medications below are not specifically recommended by Dr Daniel Gorman, the Tourette Syndrome Foundation of Canada, or the TS Ottawa Chapter, and you should consult with a licensed medical professional before taking any medication.

The following is based on the presentation “Medication Treatment for Individuals with Tourette Syndrome and Associated Conditions” by Daniel Gorman, MD, FRCPC (Staff Psychiatrist, The Hospital for Sick Children, Assistant Professor, University of Toronto), given at the Tourette Syndrome Foundation of Canada International Symposium and National Conference , on September 16, 2006, except where otherwise noted.

Medications for Tourette Syndrome

Alpha-2 agonists: Clonidine, Guanfacine (not available in CRisperidone

Side Effects and Risks for Alpha-2 Agonist Medications: sedation, dry mouth, constipation, nausea, vomiting, irritability, depressed mood, dizziness, low blood pressure and heart rate, high blood pressure if the mediation is stopped suddenly, and heart rhythm changes.

“Atypical” antipsychotics: Olanzapine, Quetiapine, Ziprasidone (not available in Canada), Aripiprazole (not available in Canada)

Side Effects and Risks for “Atypical” Antipsychotic Medications:
sedation, weight gain, diabetes, high cholesterol and triglycerides, dry mouth, constipation, difficulty urinating, cognitive dulling, low blood pressure, restlessness, anxiety, tremor, muscle rigidity, hormonal changes affecting menstruation, abnormal movements (rare, but may be permanent), heart rhythm abnormalities (rare), and “Neuroleptic malignant syndrome” (rare).

“Typical” antipsychotics: Haloperidol, Pimozide/Orap

Side Effects and Risks for “Typical” Antipsychotic Medications:
muscle rigidity, tremor, restlessness, anxiety, hormonal changes affecting menstruation, abnormal movements (may be permanent), constipation, difficulty urinating, cognitive dulling, low blood pressure, sedation, weight gain, diabetes, high cholesterol and triglycerides, dry mouth, heart rhythm abnormalities (rare), and “Neuroleptic malignant syndrome” (rare).
Other Agents: Pergolide, Botulinum toxin, Tetrabenazine (not available in USA), Benzodiazepines, Baclofen, Topiramate, and Levetiracetam.

A medication which was not listed in Dr Gorman’s presentation is Seroquel.

Medications for Attention Deficit Disorder with or without Hyperactivity

Stimulants (may increase tics): Ritalin, Adderall, Dexedrine
Stratera (Atommoxetine).

Medications for Obsessive Compulsive Disorder
SSRIs: Prozac, Zoloft, Luvox, Selexa , Anafranil.

Alternate treatment: Cognitive Behavioural Therapy.
Medication for Sleep Disorder: Melatonin.

Lawrence Zuker, President of th Ottawa Chapter of the Tourette Syndrome Foundation of Canada has written this article based on a presentation at the Tourette Syndrome Foundation of Canada’s National Conference in Edmonton, Alberta, September 2006
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