David Baxter PhD
Late Founder
Specific dopamine receptors control perceptions of emotional events
by Jeff Renaud
Tuesday, 21 April 2009
Research finds potential therapeutic targets for controlling emotional perception and memory deficits linked to PTSD and Schizophrenia
Research conducted by Nicole Lauzon and Dr Steven Laviolette of the Schulich School of Medicine & Dentistry at The University of Western Ontario, Canada has found key processes in the brain that control the emotional significance of our experiences and how we form memories of them.
A lack of proper brain function in this area may underlie such conditions as Schizophrenia and Post-Traumatic Stress Disorder (PTSD). In people who suffer from these disorders emotional experiences can become distorted, causing the person to 'lose touch' with reality. The findings have been published online by The Journal of Neuroscience.
Lauzon, a Doctoral graduate student in the Laviolette laboratory, discovered that specific receptors for the neurotransmitter dopamine can control how the brain processes emotionally significant information as well as memories for those experiences. Using a rodent model of emotional learning and memory formation, the researchers found by increasing the activity of a specific dopamine receptor in a region of the brain called the prefrontal cortex, it was able to transform a normally insignificant emotional experience into a very strong emotional memory. In contrast, when a different subtype of the dopamine system was activated, it was able to block the ability to recall an emotionally charged experience.
"Our findings have profound implications for understanding how specific brain receptors can control the magnitude of emotional experience and memory formation," says Laviolette.
"Targeting these receptor systems pharmacologically may offer new therapeutic treatments for controlling the emotional perception and memory deficits observed in psychiatric disorders such as Schizophrenia and PTSD." Laviolette is a professor in the Department of Anatomy & Cell Biology and a National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator.
According to the National Institute of Mental Health, over 280,000 Canadians suffer from Schizophrenia, and approximately 51 million people worldwide. About eight per cent of the population will have PTSD symptoms at some point in their lives according to the U.S. National Center for Post-Traumatic Stress Disorder.
Source: Lauzon NM, Bishop SF, Laviolette SR. Dopamine D1 versus D4 Receptors Differentially Modulate the Encoding of Salient versus Nonsalient Emotional Information in the Medial Prefrontal Cortex. J. Neurosci. 2009 Apr;29:4836-4845 [Abstract]
by Jeff Renaud
Tuesday, 21 April 2009
Research finds potential therapeutic targets for controlling emotional perception and memory deficits linked to PTSD and Schizophrenia
Research conducted by Nicole Lauzon and Dr Steven Laviolette of the Schulich School of Medicine & Dentistry at The University of Western Ontario, Canada has found key processes in the brain that control the emotional significance of our experiences and how we form memories of them.
A lack of proper brain function in this area may underlie such conditions as Schizophrenia and Post-Traumatic Stress Disorder (PTSD). In people who suffer from these disorders emotional experiences can become distorted, causing the person to 'lose touch' with reality. The findings have been published online by The Journal of Neuroscience.
Lauzon, a Doctoral graduate student in the Laviolette laboratory, discovered that specific receptors for the neurotransmitter dopamine can control how the brain processes emotionally significant information as well as memories for those experiences. Using a rodent model of emotional learning and memory formation, the researchers found by increasing the activity of a specific dopamine receptor in a region of the brain called the prefrontal cortex, it was able to transform a normally insignificant emotional experience into a very strong emotional memory. In contrast, when a different subtype of the dopamine system was activated, it was able to block the ability to recall an emotionally charged experience.
"Our findings have profound implications for understanding how specific brain receptors can control the magnitude of emotional experience and memory formation," says Laviolette.
"Targeting these receptor systems pharmacologically may offer new therapeutic treatments for controlling the emotional perception and memory deficits observed in psychiatric disorders such as Schizophrenia and PTSD." Laviolette is a professor in the Department of Anatomy & Cell Biology and a National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator.
According to the National Institute of Mental Health, over 280,000 Canadians suffer from Schizophrenia, and approximately 51 million people worldwide. About eight per cent of the population will have PTSD symptoms at some point in their lives according to the U.S. National Center for Post-Traumatic Stress Disorder.
Source: Lauzon NM, Bishop SF, Laviolette SR. Dopamine D1 versus D4 Receptors Differentially Modulate the Encoding of Salient versus Nonsalient Emotional Information in the Medial Prefrontal Cortex. J. Neurosci. 2009 Apr;29:4836-4845 [Abstract]
