Well, I had my appointment on Monday and came away guardedly optimistic. My Pdoc had checked with his colleagues, some who are very experienced with all forms and combinations of anti-depressants. He thought making a change at 6 weeks or even 8 weeks might be premature as he was advised it's not uncommon for the full positive effects to take 12 weeks for some patients. With me being a return user of Zoloft I'm not sure if that makes my acceptance of the drug that much more difficult. We also talked a lot about specific strategies for retirement and finding purpose and meaning. I'm still not doing so hot this week on Zoloft but find my late afternoons and evenings are pretty normal. I'm tempted to ask him to bump up the dosage to 250 mg but he may want to wait a week or 2 longer. As for Wellbutrin, it sounds like it's a good augmentation for Zoloft as it affects the other neurotransmitters. I'm just concerned that it might further disrupt my sleep and cause more anxiety (I know it can be expected during the first few days of taking it). I continue with the mindfulness and cognitive therapy but that's really an up and down experience for me so far. I am more aware of the anxiety (it's pretty constant) and I constantly turn toward it and fully accept that it's uncomfortable and painful but it is what it is and I can fully accept it in the moment. The problem for me with this approach is you have to do this constantly, hundreds of times over and over, similar to practising mindfulness where you bring your mind back to the present moment over and over and experience everyithing that is going on at that moment.